Aspirin and Hormone Replacement Therapy

Several other substances, including Aspirin and hormone replacement therapy (HRT), may reduce the risk of colorectal cancer. Studies that observed large groups of women suggest that both these substances may reduce a woman's risk of colorectal cancer; however, more research is needed to define their role in prevention.

Aspirin
The Nurses Health Study (see the exercise section) showed that women who took Aspirin consistently for a 20-year period had a lower risk of colorectal cancer. Regular Aspirin use, however, may also damage the lining of the stomach and the intestine. For now, Aspirin is not generally recommended as a preventive measure for colorectal cancer.

Hormone Replacement Therapy (HRT)
Hormone replacement therapy is used to reduce the symptoms of menopause. It may also reduce the risk of other conditions including colorectal cancer. Several studies have now shown that HRT reduces a woman's risk of colorectal cancer. This protection is strongest for women who are currently using, or have recently used, HRT. However, several large studies have shown that there are serious long-term risks associated with hormone therapy. HRT is also associated with an increased risk of breast and endometrial cancer. Women should discuss the risks and benefits of HRT with their doctors, when considering HRT.

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